By W. A. Hemmings (auth.), W. A. Hemmings (eds.)

ISBN-10: 9401166099

ISBN-13: 9789401166096

ISBN-10: 9401166110

ISBN-13: 9789401166119

w. A. HEMMINGS the idea that proteins can input cells entire is a tough one. but the version occasions wherein this procedure could be studied were identified and investigated for a few years. these occasions come up in the course of the specialization required to move immunoglobulins synthesized via the mummy to the flow of the fetus or baby animal, that's within the transmission of passive immunity to the younger. This regularly includes the protein crossing a continual mobile barrier, within the placenta or fetal membranes, or within the intestinal epithelium. the concept that is tough to simply accept by way of telephone biology since it is hard to envisage a mechanism wherein proteins can move in volume a telephone membrane that's regulating the access of solutes. Brambell has recommend an speculation of this sort of mechanism, restating it in 'The transmission of passive immunity from mom to younger' in 1970. In 1974, after his demise, a symposium used to be held in Bangor principally in this topic, released as 'Maternofetal Transmission of Immunoglobulins' . on the grounds that then extra conferences were hung on intestine move less than the identify of the current quantity, which consists of papers drawn from those meetings.

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J. , 255, 619 Orlic, D. and Lev, R. (1973). Fetal rat intestinal absorption of horseradish peroxidase from swallowed amniotic fluid. J. Cell. , 56, 106 Rodewald, R. (1973). Intestinal transport of antibodies in the new born rat. J. Cell. , 58, 189 POSTSCRIPT In recent fractionation studies involving centrifugation in density gradients (Morris and Morris, 1977a) and ultrafiltration techniques (Morris and Morris, 1977b), the digestion and transmission of IgG and IgG fragments by the proximal and distal regions of the small intestine have been examined.

A. (l975b). Degradation products of the Fc fragment of rabbit IgO in young rat gut tissue after injection into the ileum. S. , 3, 280 Hemmings, W. A. (1975c). Transport of protein across the small intestine of adult rats following injection of ferritin to the intestinal lumen. S. , 3, 262 Hemmings, W. A. (1975d). Transport of immunoglobulins across the gut of the adult rat. S. , 3, 282 45 ANTIGEN ABSORPTION BY THE GUT Hemmings, W. A. and Williams, E. W. (1975). Transport of ferritin across the ileum of suckling rats.

Osmium tetroxide fixation. x 2400 56 FERRITIN UPTAKE BY ADULT RAT GUT Figure 6 This is a micrograph of a magnified section of the intercellular space, showing the presence of ferritin. Some of the tracer was also observed free in the cytoplasm of the cell. Osmium tetroxide fixation. x 24000 Figure 7 A low-power view of the intercellular space between two cells. Below the nuclei is the intercellular space containing the tracer, and at higher magnification, ferritin is seen in this space. Osmium tetroxide / gluteraldehyde fixation.

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Antigen Absorption by the Gut by W. A. Hemmings (auth.), W. A. Hemmings (eds.)

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