By Shutsung Liao, John M. Kokontis, Chih-Pin Chuu, Richard A. Hiipakka (auth.), James Mohler, Donald Tindall (eds.)

ISBN-10: 0387691774

ISBN-13: 9780387691770

ISBN-10: 0387691790

ISBN-13: 9780387691794

This e-book serves as a tribute to the paintings of the various investigators who've tried to appreciate the function of the androgen receptor (AR) within the improvement and development of prostate melanoma. the connection among prostate melanoma and androgen prestige was once first and foremost liked within the past due 1800’s, after which know-how reawakened within the 1940’s through the reports of Charles Huggins and associates, for which the Nobel prize used to be presented in 1966.

The objective of this publication is to supply an up-to-the-minute overview of the molecular and mobile features of androgen motion in prostate melanoma. It comprises an outline of the position of androgens within the improvement of the traditional prostate and development of prostate melanoma. Our realizing of androgen metabolism and efforts to focus on androgen metabolism within the prevention and therapy of prostate melanoma is gifted. Androgen receptor structure/function relationships and the function of co-regulators are outlined. Ligand-independent activation of the androgen receptor and the function of the androgen receptor in the course of development to the castration recurrent phenotype are mentioned. Androgen-regulated genes are elucidated and their roles in the course of prostate melanoma development are outlined. ultimately, the androgen receptor is gifted as a practicable aim for novel treatments. jointly, those experiences should still provide the reader a complete conceptual framework of androgen motion in prostate cancer.

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Huang, I. , Hiipakka, R. A. and Liao, S. 1988. Correction of the cDNA-derived protein sequence of prostatic spermine binding protein: pivotal role of tandem mass spectroscopy in sequence analysis. Biochemistry 27:4214–4221. Anderson, K. M. and Liao, S. 1968. Selective retention of dihydrotestosterone by prostatic nuclei. Nature 219:277–279. , Bishop, R. W. and Russell, D. W. 1989. Expression cloning and regulation of steroid 5 alpha-reductase, an enzyme essential for male sexual differentiation.

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And Jensen, E. V. 1977. Antibodies to estrogen receptor: immunochemical similarity of estrophilin from various mammalian species. Proc. Natl. Acad. Sci. USA 74:3681–3685. , Sklar, G. , Borkowski, A. and Kyprianou, N. 1997. Loss of the cyclin-dependent kinase inhibitor p27(Kip1) protein in human prostate cancer correlates with tumor grade. Clin.

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Androgen Action in Prostate Cancer by Shutsung Liao, John M. Kokontis, Chih-Pin Chuu, Richard A. Hiipakka (auth.), James Mohler, Donald Tindall (eds.)


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