By Shutsung Liao, John M. Kokontis, Chih-Pin Chuu, Richard A. Hiipakka (auth.), James Mohler, Donald Tindall (eds.)
This e-book serves as a tribute to the paintings of the various investigators who've tried to appreciate the function of the androgen receptor (AR) within the improvement and development of prostate melanoma. the connection among prostate melanoma and androgen prestige was once first and foremost liked within the past due 1800’s, after which know-how reawakened within the 1940’s through the reports of Charles Huggins and associates, for which the Nobel prize used to be presented in 1966.
The objective of this publication is to supply an up-to-the-minute overview of the molecular and mobile features of androgen motion in prostate melanoma. It comprises an outline of the position of androgens within the improvement of the traditional prostate and development of prostate melanoma. Our realizing of androgen metabolism and efforts to focus on androgen metabolism within the prevention and therapy of prostate melanoma is gifted. Androgen receptor structure/function relationships and the function of co-regulators are outlined. Ligand-independent activation of the androgen receptor and the function of the androgen receptor in the course of development to the castration recurrent phenotype are mentioned. Androgen-regulated genes are elucidated and their roles in the course of prostate melanoma development are outlined. ultimately, the androgen receptor is gifted as a practicable aim for novel treatments. jointly, those experiences should still provide the reader a complete conceptual framework of androgen motion in prostate cancer.
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Additional resources for Androgen Action in Prostate Cancer
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Androgen Action in Prostate Cancer by Shutsung Liao, John M. Kokontis, Chih-Pin Chuu, Richard A. Hiipakka (auth.), James Mohler, Donald Tindall (eds.)
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