By Eric T. Wong
This concise textual content offers a whole review of alternating electrical fields treatment -- sometimes called tumor treating fields -- for glioblastoma and different forms of good tumor malignancies. Readers are given a primary knowing of this novel anti-cancer remedy modality by means of studying from medical trial information in addition to the actual and cellphone biology results on tumor cells whilst alternating electrical fields are utilized either in vitro and in vivo.
Chapters illustrate the physics in the back of electrical box propagation in house and different media. this can be by means of a assessment of our present knowing of the electrical box results on dividing cells - together with the disruption of cytokinesis, right chromosome segregation and activation at the cellphone floor chaperons that set off immunogenic telephone dying. information from part III trials for the remedy of recurrent and newly clinically determined glioblastomas are incorporated, in addition to a few of the ancillary post hoc analyses that have been played by way of numerous investigators. the rest of the bankruptcy covers different strong tumor malignancies, together with non-small cellphone lung melanoma, pancreatic melanoma and ovarian melanoma, as this remedy modality is being utilized to systemic malignancies.
Alternating electrical Fields remedy in Oncology deals oncologists, neurologists, radiation oncologists, biomedical engineers, mobile biologists and mitosis researchers the basics wanted for scientific practice.
Read or Download Alternating Electric Fields Therapy in Oncology: A Practical Guide to Clinical Applications of Tumor Treating Fields PDF
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Extra resources for Alternating Electric Fields Therapy in Oncology: A Practical Guide to Clinical Applications of Tumor Treating Fields
While most external beam radiation therapy uses ionizing radiation with beam-on time of only a few minutes per fraction, the duration of TTFields therapy is orders of magnitude longer. Therefore, on a per unit time basis, TTFields deliver a lower amount of energy to the target tissue than ionizing radiation. Nevertheless, they both damage actively dividing tumor cells and effect downstream anticancer responses. Apart from this similarity, the two types of therapies diverge in their mechanisms of action.
First, Coulomb’s law describes the electric field strength at a test point located at a distance from a charge located in space and time (Fig. 1). Specifically, the field strength decreases in an inverse proportion to the square of the distance or 1 from the charge, where r is the radial distance between the test point and the r2 charge. Fig. 1 Coulomb’s law expresses that the electric field strength drops off with the square of the distance between the charge and at a test point in space. 2 Fundamental Physics of Tumor Treating Fields 17 Fig.
Furthermore the dose dependency of TTFields , which relates to the fact that the inhibitory effect of TTFields increases rapidly with 36 C. C. Miranda Fig. 4 DEP forces on a cell during cytokinesis. (A) Close-up of the furrow region and the DEP force component plotted as arrows. (B) The normalized DEP force component for the three stages of cytokinesis. Adapted from Wenger et al. . Fig. 5 Cellular characteristics that influence DEP forces. (A) The peak frequency (kHz) of maximal DEP force component as a function of cell radius (μm) for the three stages of cytokinesis.
Alternating Electric Fields Therapy in Oncology: A Practical Guide to Clinical Applications of Tumor Treating Fields by Eric T. Wong
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